Dexamethasone steroid withdrawal

Dexamethasone suppression tests are used to assess the status of the hypothalamic-pituitary-adrenal (HPA) axis and for the differential diagnosis of adrenal hyperfunction. The low-dose dexamethasone suppression tests are used to assess nonsuppressible cortisol production by adrenal incidentalomas and to differentiate patients with Cushing's syndrome of any cause from patients who do not have Cushing's syndrome. The high-dose dexamethasone suppression tests help to distinguish patients with Cushing's disease (Cushing's syndrome caused by pituitary hypersecretion of corticotropin [ACTH]) from most patients with the ectopic ACTH syndrome (Cushing's syndrome caused by nonpituitary ACTH-secreting tumors).

The recommended dose is one or two drops (solution or ointment) or one drop (suspension) into the conjunctival sac every four to six hours. The dosing interval may be reduced to every two hours during the initial 24 to 48 hours. The hands should be washed before each use of Tobradex or any eye medication. The head is tilted back, and the lower eye lid is pulled down with the index finger to form a pouch. The tip of the dropper should not touch the eye or eyelid . The bottle of Tobradex should be squeezed slightly to allow the prescribed number of drops (generally one or two drops) into the pouch. If the ointment is being used, a small strip (about 1cm or 1/2 inch) of ointment should be squeezed into the pouch. The eye should then be closed gently for one to two minutes without blinking.

As is the case with any medication, use of dexamethasone can cause some unwanted side effects. Few, if any, patients experience all of these side effects. In fact, some patients do not experience any side effects at all while taking dexamethasone. There are certain precautionary measures that patients and their healthcare providers should take in order to reduce or avoid adverse effects. The most important side effects and precautions are described here. Members of your healthcare team can provide more information in greater detail about these and other possible side effects. They also can make recommendations about managing these side effects if they occur.

Tobramycin/dexamethasone ( INNs , trade name Tobradex , Tobrason in Jordan [1] ) is a prescription medication in the form of eye drops and eye ointment , marketed by Alcon . The active ingredients are tobramycin % (an antibiotic ) and dexamethasone % (a corticosteroid ). It is prescribed for a wide spectrum of bacterial eye infections. Tobradex can also be used to clear or contract styes that are also found in the eye. It is prescribed for the treatment of pink eye in combination with bacterial infections. Because it contains a steroid, careful use with gradual reduction of doses is required.

Dexamethasone has also been used during pregnancy as an off-label prenatal treatment for the symptoms of congenital adrenal hyperplasia (CAH) in female fetuses. CAH causes a variety of physical abnormalities, notably ambiguous genitalia in girls. Early prenatal CAH treatment has been shown to reduce some CAH symptoms, but it does not treat the underlying congenital disorder . This use is controversial: it is inadequately studied, only around one in ten of the foetuses of women treated are at risk of the condition, and serious adverse events have been documented. [21] Experimental use of dexamethasone in pregnancy for foetal CAH treatment was discontinued in Sweden when one in five cases suffered adverse events. [22]

Dexamethasone steroid withdrawal

dexamethasone steroid withdrawal

Tobramycin/dexamethasone ( INNs , trade name Tobradex , Tobrason in Jordan [1] ) is a prescription medication in the form of eye drops and eye ointment , marketed by Alcon . The active ingredients are tobramycin % (an antibiotic ) and dexamethasone % (a corticosteroid ). It is prescribed for a wide spectrum of bacterial eye infections. Tobradex can also be used to clear or contract styes that are also found in the eye. It is prescribed for the treatment of pink eye in combination with bacterial infections. Because it contains a steroid, careful use with gradual reduction of doses is required.

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