Ecdysteroid signaling

Q. I read your review of creatine online and found it very informational. I am wondering if you can share some information about the recent body-building supplement Ecdy Bolin. I have been using it for a couple months (both with creatine and also without). It is promoted as has other benefits aside from muscle-building, such as nerve function. Anyway, I would like to know if you feel this supplement is a safe and a quality addition and how you feel about it in general. At the moment, I am not using creatine, only Ecdy Bolin.
   A. An internet search reveals Ecdy Bolin has 100 mg of ecdysterone. I have not seen any human studies with Ecdy Bolin or ecdysterone, so I have no opinion on this supplement at this time.

Because of their chemical stability and lipophilicity, many organochlorine compounds (OCs) can readily accumulate in fatty tissues of crustaceans. Several OCs have been reported to inhibit crustacean molting. To determine whether the disruption of crustacean molting by these OCs involves interference with ecdysteroid signaling in the epidermis, the impacts of five molt-inhibiting OCs on the level of N-acetyl-beta-glucosaminidase (NAG, EC ) mRNA in cultured epidermal tissues from the fiddler crab, Uca pugilator, were investigated using quantitative real-time PCR. The NAG mRNA was found to be inducible by 20-hydroxyecdysone (20-HE) in cultured epidermal tissues. The inducibility of NAG mRNA in cultured epidermal tissues by 20-HE is not only further direct evidence that epidermal expression of NAG gene in U. pugilator is controlled by the molting hormone but also validates the use of the NAG mRNA as a biomarker for epidermal ecdysteroid signaling. When Aroclor 1242, 2,4,5-trichlorobiphenyl (PCB29), endosulfan or kepone was administered alone, the expression of NAG gene in cultured epidermal tissues was upregulated, while heptachlor had no effects. Under binary exposure to both 20-HE and an OC, a condition similar to the natural hormonal milieu of epidermal tissues of animals impacted by OCs, both Aroclor 1242 and endosulfan were found to be capable of antagonizing ecdysteroid signaling in cultured epidermal tissues. This antagonizing effect on epidermal ecdysteroid signaling can at least partly explain the inhibitory effects of these two agents on crustacean molting. PCB29, when given together with 20-HE, produced an additive effect on epidermal ecdysteroid signaling but such an additive effect was not observed when kepone was combined with 20-HE.

The European eel has a number of metamorphoses, from the larval stage to the leptocephalus stage, then a quick metamorphosis to glass eel at the edge of the continental shelf (eight days for the Japanese eel), two months at the border of fresh and salt water where the glass eel undergoes a quick metamorphosis into elver, then a long stage of growth followed by a more gradual metamorphosis to the migrating phase. In the pre-adult freshwater stage, the eel also has phenotypic plasticity because fish-eating eels develop very wide mandibles, making the head look blunt. Leptocephali are common, occurring in all Elopomorpha (tarpon- and eel-like fish).

Ecdysteroid signaling

ecdysteroid signaling

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