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Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

In any case, regardless of total dosing most Deca-Durabolin use will extend to at least 8 weeks, with 10-12 weeks being optimal. Remember, because of the Decanoate ester attached this is an extremely slow acting anabolic steroid; just look at the long half-life that is 15 days and you can see this fact. Due to this fact, gains will come very slow, and most will not see much due to use until 4-6 weeks have passed. At any rate, it is also recommended you end all Deca-Durabolin use at least 2 weeks before your total cycle ends. For example, if you were stacking Testosterone and Deca-Durabolin in a 12 week plan, you would end your Deca-Durabolin use at the end of week 10 and continue to supplement with Testosterone for two more weeks. If you end a cycle with Deca-Durabolin, because it is so suppressive and stays in your system for so long it will make recovery far more difficult than it needs to be.

As for individual use of a personal nature, outside therapeutic treatment, this is where we will find the vast majority of anabolic steroids. It is here we will also find the biggest problems, not in terms of ill-effects of a physical or mental nature but of those surrounding legality. In places like the . anabolic steroids are controlled substances, and here we will find the strictest of laws. This has created a new class of criminal; most commonly an adult man with a family who is simply living an every day life like everyone else. These are issues that need to be discussed and you will find very few are willing to touch them unlike .

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