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Even with a growing number of doctors making the connection between the behavioral symptoms and Tamiflu, both the FDA and the drug's maker, Roche, say there is not enough clear evidence to establish a direct cause-and-effect relationship between the drug and the abnormal behaviors. They note that severe cases of the flu virus itself can cause adverse psychiatric symptoms, so it's very difficult to determine if the behaviors are a result of the flu or of the antiviral drug being taken to treat it. One of the major concerns right now is that Tamiflu is the only approved, oral neuraminidase inhibitor on the market, and experts believe it will be a crucial tool in stopping a bird-flu pandemic if the disease ever mutates into a form that transmits easily from human to human. In the current climate, the FDA does not want to imply that Tamiflu is unsafe without very solid evidence to that effect. Also, discouraging people from taking Tamiflu could end up increasing the number of deaths from the untreated flu virus.
The following adverse reactions have been identified during postapproval use of risperidone. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These adverse reactions include: alopecia , anaphylactic reaction, angioedema , atrial fibrillation , cardiopulmonary arrest, diabetic ketoacidosis in patients with impaired glucose metabolism , dysgeusia, hypoglycemia , hypothermia , ileus , inappropriate antidiuretic hormone secretion, intestinal obstruction, jaundice , mania, pancreatitis , pituitary adenoma , precocious puberty, pulmonary embolism , QT prolongation, sleep apnea syndrome, sudden death, thrombocytopenia , thrombotic thrombocytopenic purpura , urinary retention, and water intoxication .