Steroid effects on cats

NSAIDS have antipyretic activity and can be used to treat fever. [75] [76] Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation. [75] [77] Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus . [75] [76] PGE2 signals to the hypothalamus to increase the body's thermal set point. [76] [78] Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen). [77] [79] Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.

The target organ for atopy (unlike the respiratory signs in people) is the skin. Cats may have many different areas of the body affected, making this problem difficult to differentiate from other skin diseases. Often, after eliminating more easily diagnosed problems, veterinarians will try a steroid trial. This involves either an oral medication given daily or an injection given every 6-8 weeks, as needed. The daily medication allows for more precise dosing and less risks of side effects but can be difficult with some cats (to say the least!). An alternative medication called cyclosporine is more in favor now due to fewer side effects; however, it is a more expensive option.

Cats sometimes have trouble metabolizing prednisone. That is why some are prescribed prednisolone instead. It is basically the same drug, but it is already in the form it would be after being processed in the liver. Prednisolone side effects in cats should be the same as the prednisone side effects. Since prednisone works as an immune suppressant, you should watch for the signs of an infection in your cat when it is taking this drug, especially if it is on a high dose as such a dose will significantly compromise the immune system. That is why high doses are only used in connection with serious conditions such as cancer.

Steroids killed nine-year-old Lexie McConnell after only five and a half weeks. In August 1993, Lexie was diagnosed as having toxoplasmosis. The consultant put her on 80 mg per day of prednisolone. Immediately, she suffered severe side effects, huge weight gain , terrible pains, holes in her tongue and black stools. After nearly a month, at her parents' pleading, the doctors quickly lowered the dosage to 60 mg, 40 mg, 20 mg. In excruciating pain, Lexie was taken to a hospital, where it was discovered she'd contracted chickenpox. Four days later, she died. A few years later, another eye specialist declared that a simple course of antibiotics could have cleared up her infection. The above excerpt is from Ursula Kelly's site

Steroid effects on cats

steroid effects on cats

Steroids killed nine-year-old Lexie McConnell after only five and a half weeks. In August 1993, Lexie was diagnosed as having toxoplasmosis. The consultant put her on 80 mg per day of prednisolone. Immediately, she suffered severe side effects, huge weight gain , terrible pains, holes in her tongue and black stools. After nearly a month, at her parents' pleading, the doctors quickly lowered the dosage to 60 mg, 40 mg, 20 mg. In excruciating pain, Lexie was taken to a hospital, where it was discovered she'd contracted chickenpox. Four days later, she died. A few years later, another eye specialist declared that a simple course of antibiotics could have cleared up her infection. The above excerpt is from Ursula Kelly's site

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