Steroid-sparing agents

Ten trials involving a total of 185 people were included. Study design and quality, corticosteroid dosages and outcomes varied widely. There was a reduction in oral corticosteroid dose favouring methotrexate in parallel trials ( weighted mean difference - mg per day, 95% confidence interval - to -) and also in cross-over trials ( weighted mean difference - mg per day, 95% confidence interval - to -). There was no difference between methotrexate and placebo for forced expiratory volume in one minute ( weighted mean difference litre, 95% confidence interval - to ). Hepatotoxicity was a common adverse effect with methotrexate compared to placebo ( odds ratio , 95% confidence interval to ).

Steroid-sparing agents

steroid-sparing agents

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